B7651
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B7651
Sigma
Brefeldin A
from Penicillium brefeldianum, ≥99% (HPLC and TLC)
| Synonym: | Ascotoxin, BFA, Cyanein, Decumbin, γ,4-Dihydroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic acid λ-lactone |
| CAS Number: | 20350-15-6 |
| Linear Formula: | C16H24O4 |
| Molecular Weight: | 280.36 |
| Beilstein Registry Number: | 25191 |
| MDL number: | MFCD00083258 |
| PubChem Substance ID: | 24278285 |
Description
| Biochem/physiol Actions | Brefeldin A (BFA) is a fungal metabolite which disrupts the structure and function of the Golgi apparatus. BFA is an activator of the sphingomyelin cycle. Brefeldin A-mediated apoptosis has been observed in human tumor cells. |
Properties
| biological source | from Penicillium brefeldianum |
| assay | ≥99% (HPLC and TLC) |
| solubility | ethanol: 10 mg/mL Store stock solutions at -20 °C. |
| methanol: 10 mg/mL Store stock solutions at -20 °C. | |
| storage temp. | 2-8°C |
Safety
| Personal Protective Equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| RIDADR | UN2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | GY8410000 |
References
| reference | Dinter, A. and Berger, E.G., Golgi-disturbing agents. Histochem. Cell Biol. 109, 571-590, (1998) Abstract |
| Linardic, C.M., et al., Activation of the sphingomyelin cycle by brefeldin A: effects of brefeldin A on differentiation and implications for a role for ceramide in regulation of protein trafficking. Cell. Growth Differ. 7, 765-774, (1996) Abstract | |
| Guo, H., et al., Brefeldin A-mediated apoptosis requires the activation of capases and is inhibited by Bcl-2. Exp. Cell Res. 245, 57-68, (1998) Abstract | |
| Shao, R.G., et al., Brefeldin A is a potent inducer of apoptosis in human cancer cells independently of p53. Exp. Cell Res. 227, 190-196, (1996) Abstract | |
| Merck | Merck 13,1355 |
| Beilstein | Beil. 18,IV,1220 |
